Final height and gonad function after total body irradiation during childhood

Hyperparathyroidism in Survivors of Childhood Malignancy after Total Body Irradiation

Objective: The risk of developing hyperparathyroidism (HPT) in adults after radiation exposure is higher than that of the general population. Extensive follow up guidelines of United Kingdom Children’s Cancer Study group (UKCCSG) or Scottish intercollegiate guidelines network (SIGN) do not recommend monitoring serum calcium or parathyroid hormone in patients treated for childhood malignancies. ...

Final height after transplantation in childhood.

Malignant and benign thyroid nodules after total body irradiation preceding hematopoietic cell transplantation during childhood.

BACKGROUND The risk of radiation-induced benign and malignant thyroid nodules is well known. OBJECTIVE The aim of this study was to determine the occurrence of thyroid nodules and carcinomas after fractionated total body irradiation (TBI) preceding hematopoietic stem cell transplantation (HSCT) for malignant hematological disease during childhood. METHODS We conducted a retrospective univer...

Endocrine deficit after fractionated total body irradiation.

Endocrine function was assessed in 31 children (17 boys) after fractionated total body irradiation used in the preparative regimen for bone marrow transplantation. Endocrine dysfunction was present in 25 children. Fifteen of 29 had growth hormone insufficiency 0.9-4.9 years after total body irradiation, yet only three of the 15 had received previous cranial irradiation. Five of 30 had thyroid d...

Recovery of spermatogenesis after total-body irradiation.

criteria and 40% in the best schedule (5-day intravenous). This compares favorably with prior experiences with decitabine and 5-azacitidine (CR rates, 6%-20%).4,5 Also, decitabine was less toxic than 5-azacitidine in relation to nausea/vomiting and local skin reactions (pain and induration in 5%-10% of patients on 5-azacitidine). The incidence of 65% of hospitalization is cumulative. As one del...